Tyler Payne
Tyler Payne, MBA — Founder, HelixWrks
Twelve years across every layer of the molecular workflow, most recently as a staff product manager at Illumina. Everything here comes from problems I watched go unsolved.
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Start here · Evaluating a platform purchase?
The costs labs miss before buying →
Start here · Own systems that fight you?
How technical debt caps your lab →
ArticleLIMS

Why LIMS Implementations Fail

Six patterns that play out repeatedly across genomics, molecular diagnostics, and clinical lab environments. The culprit is almost never the technology.

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ArticleLab Strategy

Laboratory Technical Debt

High-throughput platforms sitting well below capacity. Leadership won’t approve expansion. The overhead per sample makes growth uneconomical. How technical debt accumulates—and the path out.

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ArticleLab Strategy

Why End-to-End Workflow Projects Stall — and How to Fix It

How to right-size your E2E architecture for your stage of growth, find your rate-limiting steps before you buy anything, and reframe your lab as a profit center.

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ArticleTCO

The Costs Labs Miss Before Buying a Molecular Platform

The seven costs labs miss before they buy — and how to model true cost of adoption.

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ArticleLab Strategy

When Compromise Becomes Infrastructure

Every lab accepts compromises that fade into the operational background. Years later, they’re not decisions anymore — they’re infrastructure. How growing labs name and quantify what they stopped seeing.

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ArticleDeployment

Cloud vs. On-Prem: Why Your 2020 Answer May Be Wrong in 2026

The cloud vs. on-prem analysis that produced clean answers from 2017–2023 no longer holds without revisiting. A structured framework for lab leadership re-evaluating deployment strategy with current inputs.

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FrameworkLab Readiness

Lab Readiness Quick-Check

A 33-question interactive check across 10 domains — about 8 minutes, free. Know your gaps before you commit to a platform.

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FrameworkLIMS

LIMS Evaluation Scorecard

Score and compare LIMS vendors across deployment, integration, no-code capability, custom code exposure, workflow fit, and post-go-live support — built from real RFP experience on both sides of the table. Free.

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FrameworkDeployment

Deployment Discovery Framework

A 24-question interactive framework across 8 factors — about 6 minutes, free. Produces a directional hypothesis — cloud, hybrid, or on-prem — for your leadership team to pressure-test. Not a verdict.

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My Story

Twelve Years Across Every Layer of the Molecular Workflow

I started my career at the end of the genomics chain and, twelve years later, owned the whole thing. HelixWrks exists to build for the problems I spent those years watching go unsolved.

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