Tyler Payne
Tyler Payne, MBA · Founder, HelixWrks
Twelve years across every layer of the molecular workflow, most recently as a staff product manager on the vendor side. Everything here comes from problems I watched go unsolved.
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ArticleLIMS

Why LIMS Implementations Fail

Seven patterns that play out repeatedly across genomics, molecular diagnostics, and clinical lab environments. The culprit is almost never the technology.

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ArticleLab Strategy

Laboratory Technical Debt

High-throughput platforms sitting well below capacity. Leadership won’t approve expansion. The overhead per sample makes growth uneconomical. How technical debt accumulates, and the path out.

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ArticleLab Strategy

Why End-to-End Workflow Projects Stall — and How to Fix It

How to right-size your E2E architecture for where you're headed, find your rate-limiting steps before you buy anything, and get your lab funded as the investment it is.

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ArticleTCO

The Costs Labs Miss Before Buying a Molecular Platform

The seven costs labs miss before they buy, and how to model true cost of adoption.

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ArticleReimbursement

The Reimbursement Ceiling

A molecular lab doesn’t set its own price. CLFS and payer contracts set the ceiling; cost per reportable is the only lever you control. How to find which lines go underwater before a rate takes effect.

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ArticleLab Strategy

When Compromise Becomes Infrastructure

Every lab accepts compromises that fade into the operational background. Years later, they’re not decisions anymore; they’re infrastructure. How growing labs name and quantify what they stopped seeing.

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ArticleDeployment

Cloud vs. On-Prem: Why Your 2020 Answer May Be Wrong in 2026

The cloud vs. on-prem analysis that produced clean answers from 2017–2023 no longer holds without revisiting. A structured framework for lab leadership re-evaluating deployment strategy with current inputs.

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FrameworkLab Readiness

Lab Readiness Quick-Check

A 34-question interactive check across 10 domains, about 8 minutes, free. Know your gaps before you commit to a platform.

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FrameworkLIMS

LIMS Evaluation Scorecard

Score and compare LIMS vendors across deployment, integration, no-code capability, custom code exposure, workflow fit, and post-go-live support, built from real RFP experience on both sides of the table. Free.

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FrameworkDeployment

Deployment Discovery Framework

A 24-question interactive framework across 8 factors, about 6 minutes, free. Produces a directional hypothesis (cloud, hybrid, or on-prem) for your leadership team to pressure-test. Not a verdict.

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My Story

Twelve Years Across Every Layer of the Molecular Workflow

I started my career at the end of the genomics chain and, twelve years later, owned the whole thing. HelixWrks exists to build for the problems I spent those years watching go unsolved.

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